Viruses, Free Full-Text

Por um escritor misterioso

Descrição

Nucleus accumbens-associated protein 1 (NAC1) is a transcription co-factor that has been shown to possess multiple roles in stem cell and cancer biology. However, little is known about its roles in regulation of the immune system. In the current study, we observed that expression of NAC1 impacted the survival of CD8+ T cells in vitro. NAC1−/− CD8+ T cells displayed lower metabolism, including reduced glycolysis and oxidative phosphorylation. In vivo, compared with wild-type (WT) mice, NAC1−/− mice produced a lower response to vaccinia virus (VACV) infection, and viral antigen (Ag)-specific CD8+ T cells decreased more slowly. Additionally, we observed that the NAC1−/− mice demonstrated a stronger memory formation of viral Ag-specific CD8+ T cells post-viral infection. Mechanically, we identified that compared with WT CD8+ T cells, the Interferon Regulatory Factor 4 (IRF4), a key transcription factor in T cell development, was highly expressed in NAC1−/− CD8+ T cells, insinuating that IRF4 could be a critical regulatory target of NAC1 in the memory formation of CD8+ T cells. Our results indicate that NAC1 restrains the memory formation of CD8+ T cells by modulating IRF4, and targeting NAC1 may be exploited as a new approach to boosting CD8+ T cell memory.
Viruses, Free Full-Text
How Do I Know If My Phone Has a Virus + Removing Them - Panda Security
Viruses, Free Full-Text
Viruses take center stage in cellular evolution
Viruses, Free Full-Text
The ABCs of Malware A Small-Business Owner's Guide to
Viruses, Free Full-Text
Free Hand Drawn Viruses and Bacterias — Medialoot
Viruses, Free Full-Text
Abstract Display Option Added For PubMed Labs Search Results. NLM
Viruses, Free Full-Text
Avast free antivirus. It may appear rational that anti-virus…
Viruses, Free Full-Text
The Viral Life Cycle
Viruses, Free Full-Text
How to Clean your Phone from Virus
Viruses, Free Full-Text
Avira Free Security Review
Viruses, Free Full-Text
PDF) Impact of impulsive detoxication on the spread of computer virus
Viruses, Free Full-Text
Difference between Virus and Virion
Viruses, Free Full-Text
Downloading Virus Trojan_horse.exe POP-UP Scam - Removal and
de por adulto (o preço varia de acordo com o tamanho do grupo)